Brechin defenders Gerry McLaughlan, Ewan Moyes and David Whyte all miss the trip to Dumfries through injury.
But the Glebe Park men do have Dougie Hill available after he joined on loan from Raith Rovers as cover.
Queen of the South manager Kenny Brannigan:
"It has hardly been an ideal time and hopefully we can get going against Brechin.
"We need to be ready from the kick-off as they have players who can score goals.
"And we have to be prepared to work from the first whistle as hard as we were before the snow came."
Brechin manager Jim Weir:
"Queen of the South are favourites for this game and so they should be with the firepower they have.
"Willie McLaren, Allan Johnston, Derek Holmes and David Weatherston are all good attackers that will need to be stopped to allow us to play our game.
"We are going down there to win, but it will take a great performance from every Brechin player to achieve that."
Source: BBC Sport
Source: BBC Sport